Marburg an der Lahn, Germany

In 1264, St Elizabeth's daughter Sophie of Brabant, succeeded in winning the Landgraviate of Hessen, hitherto connected to Thuringia, for her son Henry. Marburg (alongside Kassel) was one of the capitals of Hessen from that time until about 1540. Following the first division of the landgraviate, it was the capital of Hessen-Marburg from 1485 to 1500 and again between 1567 and 1605. Hessen was one of the more powerful second-tier principalities in Germany. Its "old enemy" was the Archbishopric of Mainz, the seat of one of the prince-electors, who competed with Hessen in many wars and conflicts for coveted territory, stretching over several centuries.

After 1605, Marburg became just another provincial town, known mostly for the University of Marburg. It became a virtual backwater for two centuries after the Thirty Years' War (1618–48), when it was fought over by Hessen-Darmstadt and Hesse-Kassel. The Hessian territory around Marburg lost more than two-thirds of its population, which was more than in any later wars (including World War I and World War II) combined.

Marburg is the seat of the oldest existing Protestant-founded university in the world, the University of Marburg (Philipps-Universität-Marburg), founded in 1527. It is one of the smaller "university towns" in Germany. These include Greifswald, Erlangen, Jena, and Tübingen, as well as the city of Gießen, which is located 30 km south of Marburg.

In 1529, Philipp I of Hesse arranged the Marburg Colloquy, to propitiate Martin Luther and Huldrych Zwingli.

Owing to its neglect during the entire 18th century, Marburg – like Rye or Chartres – survived as a relatively intact Gothic town, simply because there was no money spent on any new architecture or expansion. When Romanticism became the dominant cultural and artistic paradigm in Germany, Marburg became a centre of activities once again, and many of the leaders of the movement lived, taught, or studied in Marburg. They formed a circle of friends that was of great importance, especially in literature, philology, folklore, and law.

The group included Friedrich Carl von Savigny, the most important jurist of his day and father of the Roman Law adaptation in Germany, as well as the poets, writers, and social activists Achim von Arnim, Clemens Brentano, and especially Bettina von Arnim, Clemens Brentano's sister, who became Achim von Arnim's wife. Most famous internationally, however, were the Brothers Grimm, who collected many of their fairy tales here. The best-known illustrations for the fairy tale editions are by the painter Otto Ubbelohde, who also lived in and near Marburg. The original building inspiring his drawing Rapunzel's Tower stands in Amönau near Marburg. Across the Lahn hills, in the area called Schwalm, the costumes of little girls included a red hood.

In the Austro-Prussian War of 1866, the Prince-elector of Hessen had backed Austria. Prussia won and took the opportunity to invade and annex the Electorate of Hessen (as well as Hanover, the city of Frankfurt, and other territories) north of the Main River. However, the pro-Austrian Hesse-Darmstadt remained independent. For Marburg, this turn of events was very positive, because Prussia decided to make Marburg its main administrative centre in this part of the new province Hessen-Nassau and to turn the University of Marburg into the regional academic centre. Thus, Marburg's rise as an administrative and university city began. As the Prussian university system was one of the best in the world at the time, Marburg attracted many respected scholars. However, there was hardly any industry to speak of, so students, professors, and civil servants – who generally had enough but not much money and paid very little in taxes – dominated the town.

Franz von Papen, vice-chancellor of Germany in 1934, delivered an anti-Nazi speech at the University of Marburg on 17 June.

During World War II, Marburg suffered much less compared to its neighbours Giessen, Siegen and Frankfurt. The city was not seen as a target of opportunity by the Allies and lacked any important industrial sites. Nonetheless, it was still bombed 13 times, mainly by the United States Army Air Forces, during the bombing of Marburg. From 1942 to 1945, the entire city of Marburg was turned into a hospital, with schools and government buildings turned into wards to augment the existing hospitals. By the spring of 1945, there were over 20,000 patients – mostly wounded German soldiers. The most significant damage happened at the north side of the city and along the marshalling yards, but the inner city was largely spared, meaning that it survived the war largely intact.